Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 39, Issue 1, Pages 9-15Publisher
ELSEVIER
DOI: 10.1016/j.etap.2014.10.015
Keywords
Bisphenol A; LH; FSH; Estradiol; Prepubertal rats; Folliculogenesis
Funding
- University of Buenos Aires, Argentina [UBACYT 20020090200125]
Ask authors/readers for more resources
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 mu g/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available