Journal
SOFT MATTER
Volume 13, Issue 6, Pages 1235-1243Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sm02188c
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Funding
- Generalitat de Catalunya [2014-SGR-878, 2014-SGR-927,]
- Spanish Government
- ICREA Funding Source: Custom
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Collective cell migration in spreading epithelia in controlled environments has become a landmark in our current understanding of fundamental biophysical processes in development, regeneration, wound healing or cancer. Epithelial monolayers are treated as thin layers of a viscous fluid that exert active traction forces on the substrate. The model is exactly solvable and shows a broad range of applicabilities for the quantitative analysis and interpretation of force microscopy data of monolayers from a variety of experiments and cell lines. In addition, the proposed model provides physical insights into how the biological regulation of the tissue is encoded in a reduced set of time-dependent physical parameters. In particular the temporal evolution of the effective viscosity entails a mechanosensitive regulation of adhesion. Besides, the observation of an effective elastic tensile modulus can be interpreted as an emergent phenomenon in an active fluid.
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