Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 39, Issue 1, Pages 53-69Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2014.11.006
Keywords
Rhizoma Coptidis; Fibrous root; Pharmacological activities; Acute toxicity; Sub-chronic toxicity; Mutagenicity
Funding
- Technology Pillar Program of China [2011BAI13B02-1]
- Chongqing Engineering and Technical Talent Program
Ask authors/readers for more resources
The aim of this study was to investigated the pharmacological activities and safety of fibrous root of Rhizoma Coptidis (FRC). FRC not only protected Kunming mice from the minimal lethal dose of Escherichia coli, but also protected rabbits from hyperpyrexia induced by lipopolysaccharid (LPS). The acute toxicity study showed that oral medial lethal dose (LD50) of FRC was greater than 7000 mg/kg body weight in Kunming mice. The sub-chronic toxicity study showed that the no-observed-adverse effect level (NOAEL) of FRC was 1.88 g/kg body weight in Sprague-Dawley rats, whereas FRC at higher dose (3.76 g/kg body weight) resulted in damage to liver and lung. Negative results were present in Ames test, mouse micronucleus test and mouse sperm abnormality test. These finding support the use of FRC in veterinary medicine. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available