Journal
SOFT MATTER
Volume 13, Issue 11, Pages 2174-2180Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sm00174f
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Funding
- National Science Foundation [CBET 12-36086]
- Division Of Physics
- Direct For Mathematical & Physical Scien [1522467] Funding Source: National Science Foundation
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We describe a method to extract force and diffusion parameters from single trajectories of Brownian particles. The analysis, based on the principle of maximum likelihood, is well-suited for out-of-equilibrium trajectories, even when a limited amount of data is available and the dynamical parameters vary spatially. We substantiate this method with experimental and simulated data, and discuss its practical implementation, strengths, and limitations.
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