Journal
SMALL
Volume 13, Issue 29, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201700963
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Funding
- NTU-Northwestern Institute for Nanomedicine
- Senior Visiting Scholar Foundation of the State Key Laboratory of Molecular Engineering of Polymers in the Fudan University [16FGJ06]
- State Key Basic Research Program of China [2012CB932403, 2015CB931800]
- National Natural Science Foundation of China [21231004, 21628401]
- International Postdoctoral Exchange Fellowship Program - China Postdoctoral Science Foundation
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Inhomogeneous heating by photothermal therapy (PTT) during cancer treatment often results in the recurrence of tumors. Thus, integrating PTT with chemotherapy (CHT) may provide a complementary treatment for enhanced therapeutic efficiency. Herein, this study develops a hollow structured polymer-silica nanohybrid (HPSN) as a nanocarrier to simultaneously deliver the anticancer drug paclitaxel and photothermal agent palladium phthalocyanine to tumors through enhanced permeation and the retention effect. A combinational CHT/PTT therapy on mice bearing aggressive tumor grafts is conducted. The highly malignant tumor model, which recurs after sole treatment of PTT, can be eradicated by the combined CHT/PTT treatment. In addition, most of the off-targeted HPSN nanocarriers can be excreted through a hepatobiliary pathway in about 10 d. Serology results show that the fast-clearable HPSN can significantly reduce the side effect of the loaded paclitaxel drug. The present work provides an alternative approach for combinational cancer treatment with high therapeutic efficiency.
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