Journal
SMALL
Volume 14, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201702671
Keywords
ast; afm; nanomotion; slow-growing bacteria
Categories
Funding
- Swiss National Grant [200021-144321, 407240_167137]
- Gebert Ruf Stiftung [GRS-024/14]
- Agencia Nacional de Promocion Cientifica y Tecnologica (MINCYT, FONCYT) of Argentina [PICT2012-2514]
- CONICET
Ask authors/readers for more resources
Infectious diseases are caused by pathogenic microorganisms and are often severe. Time to fully characterize an infectious agent after sampling and to find the right antibiotic and dose are important factors in the overall success of a patient's treatment. Previous results suggest that a nanomotion detection method could be a convenient tool for reducing antibiotic sensitivity characterization time to several hours. Here, the application of the method for slow-growing bacteria is demonstrated, taking Bordetella pertussis strains as a model. A low-cost nanomotion device is able to characterize B. pertussis sensitivity against specific antibiotics within several hours, instead of days, as it is still the case with conventional growth-based techniques. It can discriminate between resistant and susceptible B. pertussis strains, based on the changes of the sensor's signal before and after the antibiotic addition. Furthermore, minimum inhibitory and bactericidal concentrations of clinically applied antibiotics are compared using both techniques and the suggested similarity is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available