Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
Volume 7, Issue 4, Pages 188-192Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/jphi.JPHI_82_17
Keywords
Curcumin; local drug delivery; ornidazole
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Objective: The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis. Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths > 5 mm bilaterally were selected for this study, in a split-mouth design. Examination of plaque index, probing pocket depth, and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) > 5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss, and plaque index were recorded at days 0 and 30. Results: At 1-month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index, and clinical attachment loss when compared to the ornidazole group. Conclusion: The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.
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