Journal
ADVANCED SCIENCE LETTERS
Volume 23, Issue 6, Pages 5941-5943Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/asl.2017.9075
Keywords
Phillipsite-Rich Rock; Surface Modification; Diclofenac; Ibuprofen; Loading Kinetic; Release Kinetic
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Funding
- MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca)
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This work aims at investigating the possible use of phillipsite (PHI), surface modified with cetylpyridinium chloride (CP), for the prolonged release of non-steroidal anti-inflammatory drugs (NSAIDs) as diclofenac (DS) and ibuprofen (IBU). Drug loading and in vitro drug release kinetics, in simulated intestinal fluid (SIF), were investi-gated to assess the relationship between rock mineralogy and their pharmaceutical properties. Results showed that drug loading was very rapid, although the amount of DS loaded was greater. This might suggest that the loading process of DS consists both in the anion exchange on the surface modified zeolite (SMZ) and in the adsorption within the patchy bilayer. On the contrary, IBU is able to bind to the carrier almost exclusively by ion exchange. Moreover, NSAIDs release in an ionic medium, such as SIF, can be sustained for about 5 hours through a mechanism prevalently governed by anionic exchange, confirming the potentiality of this carrier in pharmaceutical applications.
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