4.3 Article

Comparison of two home sleep testing devices with different strategies for diagnosis of OSA

Journal

SLEEP AND BREATHING
Volume 22, Issue 1, Pages 139-147

Publisher

SPRINGER HEIDELBERG
DOI: 10.1007/s11325-017-1547-9

Keywords

Sleep disordered breathing; Oximetry; Portable monitoring; Obstructive sleep apnea; Limited channel monitoring

Funding

  1. NIOSH/CDC [U01OH010415]
  2. NIH K24 grant [HL109156]

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Home sleep testing devices are being widely used in diagnosis/screening for obstructive sleep apnea (OSA). We examined differences in OSA metrics obtained from two devices with divergent home monitoring strategies, the Apnea Risk Evaluation System (ARES (TM), multiple signals plus forehead reflectance oximetry) and the Nonin WristOx(2)(TM) (single channel finger transmission pulse oximeter), compared to differences from night-night variability of OSA. One hundred fifty-two male/26 female subjects (BMI = 30.3 +/- 5.6 kg/m(2), age = 52.5 +/- 8.9 years) were recruited without regard to OSA symptoms and simultaneously wore both ARES (TM) and Nonin WristOx(2)(TM) for two nights (n = 351 nights). Automated analysis of the WristOx(2) yielded oxygen desaturation index (ODIOx2, 4% O2 dips/h), and automated analysis with manual editing of ARES (TM) yielded AHI4(ARES) (apneas + hypopneas with 4% O2 dips/h) and RDIARES (apneas + hypopneas with 4% O2 dips/h or arousal surrogates). Baseline awake oxygen saturation, percent time < 90% O2 saturation (%time < 90%O2Sat), and O2 signal loss were compared between the two methods. Correlation between AHI4(ARES) and ODIOx2 was high (ICC = 0.9, 95% CI = 0.87-0.92, p < 0.001, bias +/- SD = 0.7 +/- 6.1 events/h). Agreement values for OSA diagnosis (77-85%) between devices were similar to those seen from night-to-night variability of OSA using a single device. Awake baseline O2 saturation was significantly higher in the ARES (TM) (96.2 +/- 1.6%) than WristOx(2)(TM) (92.2 +/- 2.1%, p < 0.01). There was a significantly lower %time < 90%O2Sat reported by the ARES (TM) compared to WristOx(2) (median (IQR) 0.5 (0.0, 2.6) vs. 2.1 (0.3, 9.7), p < 0.001), and the correlation was low (ICC = 0.2). OSA severity metrics predominantly dependent on change in oxygen saturation and metrics used in diagnosis of OSA (AHI4 and ODI) correlated well across devices tested. However, differences in cumulative oxygen desaturation measures (i.e., %time < 90%O2Sat) between the devices suggest that caution is needed when interpreting this metric particularly in populations likely to have significant hypoxia.

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