Journal
ANIMAL NUTRITION
Volume 3, Issue 4, Pages 313-321Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.aninu.2017.06.003
Keywords
Intestinal barrier; Pigs; Stress; Weaning; Gut health; Mast cells
Funding
- National Institutes of Health [HD072968]
- Agriculture and Food Research Initiative Competitive from the USDA National Institute of Food and Agriculture [2017-67015-26673]
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The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions (e.g., digestion, absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility. Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed. (C) 2017, Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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