Journal
SIAM JOURNAL ON IMAGING SCIENCES
Volume 10, Issue 4, Pages 2022-2048Publisher
SIAM PUBLICATIONS
DOI: 10.1137/16M1107619
Keywords
photoacoustic computed tomography; transcranial imaging; image reconstruction; elastic wave equation
Categories
Funding
- NIH [EB01696301, 5T32EB01485505]
- NSF [DMS1614305]
Ask authors/readers for more resources
Photoacoustic computed tomography (PACT) is an emerging imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the photoacoustically induced initial pressure distribution within tissue. The PACT reconstruction problem corresponds to an inverse source problem in which the initial pressure distribution is recovered from measurements of the radiated wavefield. A major challenge in transcranial PACT brain imaging is compensation for aberrations in the measured data due to the presence of the skull. Ultrasonic waves undergo absorption, scattering, and longitudinal-to-shear wave mode conversion as they propagate through the skull. To properly account for these effects, a wave-equation-based inversion method should be employed that can model the heterogeneous elastic properties of the skull. In this work, a forward model based on a finite-difference time-domain discretization of the three-dimensional elastic wave equation is established and a procedure for computing the corresponding adjoint of the forward operator is presented. Massively parallel implementations of these operators employing multiple graphics processing units are also developed. The developed numerical framework is validated and investigated in computer-simulation and experimental phantom studies whose designs are motivated by transcranial PACT applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available