Journal
SHOCK
Volume 47, Issue 1, Pages 47-51Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SHK.0000000000000704
Keywords
Corticosteroids; immunomodulation; intensive care; mortality; severe sepsis; shock
Funding
- CNPq
- FAPERJ
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For decades, corticosteroids are proposed as adjuvant therapies for severe infections. Despite mounting evidence from randomized controlled trials, there is still an intense debate regarding the role of systemic low-dose corticosteroids as a part of the treatment of septic shock. In the present article, we review the current literature and detail aspects on the pathophysiologic rationale, the current evidence, actual practice, and future directions on this topic.
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