Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 247, Issue -, Pages 736-741Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.03.049
Keywords
Ratiometric; Fluorescent probe; Forster resonance energy transfer; Hypochlorous acid; Bioimaging
Funding
- Natural Science Foundation of Shandong Province [ZR2014BM004]
- Major Project of Science and Technology of Shandong Province [2015ZDJS04001, 2015ZDJS04003]
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A ratiometric fluorescent probe (DICX) based on Forster resonance energy transfer (FRET) system for hypochlorous acid (HOCl) was developed, in which coumarin moiety was connected to rhodamine by monothio-bishydrazide linker. DICX could fast respond to HOCl under acidic condition and showed high selectivity and sensitivity toward HOCl over other reactive oxygen species, reactive nitrogen species, and ions. The FRET energy transfer efficiency is very high (93.75%). Moreover, DICX could target lysosome and could be suitable for sensing exogenous and endogenous HOCl in living cells. (C) 2017 Elsevier B.V. All rights reserved.
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