Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 251, Issue -, Pages 902-908Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.05.150
Keywords
1,8-naphthalimide; Fluorescent probe; Cysteine; Bioimaging
Funding
- Priority Academic Program Development of Jiangsu Higher Education Institutions of China
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A new fluorescent probe (ABPA) based on 1,8-naphthalimide, which designed on the receptor(1)-fluorophore-spacer-receptor(2) model and employed conjugated addition/cyclization sequence mechanism for Cys detection was reported. The probe shows high selectivity and sensitivity for cysteine (Cys) over other amino acids including the similar structured homocysteine (Hcy) and glutathione (GSH). It displays a highly sensitive fluorescence emission to Cys with a detection limit of 0.12 mu M (S/N = 3), which is far below the normal level of Cys (30-200 mu M) in living cells. Furthermore, ABPA was successfully applied to bioimage intracellular Cys in living cells with low cytotoxicity. (C) 2017 Elsevier B.V. All rights reserved.
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