Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 251, Issue -, Pages 753-762Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.05.050
Keywords
Carbon dots; Bromoacetyl bromide; Glutathione; Fluorescence
Funding
- National Natural Science Foundation of China [21374078, 51308390, 51303132]
- Application Foundation and Advanced Technology [15JCYBJC18100, 15JCTPJC59200]
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A novel fluorescent sensor based on carbon dots (CDs) was synthesized for direct determination of glutathione (GSH), which bromoacetyl bromide was functionalized CDs (CDs-Br) sensing system for the first time. The bromoacetyl bromide functional groups (halogen moiety) can quench the fluorescence of CDs, which were substituted by the -SH group, could lead to a significant fluorescence increase of CDs-Br via the halogen substitution cyclization. This method could effectively immediately detect amino acids with thiols and it needn't to be combined with metal ions. Under optimum conditions, the probe has a good selectivity for GSH over other various biologically relevant species and even two other similar biothiols(Cys/Hcy) and could image GSH in living cells. (C) 2017 Elsevier B.V. All rights reserved.
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