Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 250, Issue -, Pages 673-678Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.04.129
Keywords
Potentiometric sensor; Wearable sensor; Sweat chloride; Cystic fibrosis
Funding
- Cystic Fibrosis Foundation [SEARSO6XX0]
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The development of wearable sensors to measure biomarkers in sweat remains a major technological challenge. Here we report on a wearable, potentiometric, thin film sweat chloride sensor. Potentiometric devices provide a relatively simple technology for sweat sensing, however, equilibration between the reference and test solutions is a significant source of error. We have developed a sweat chloride sensor with integrated salt bridge that minimizes equilibration and enables stable measurements over extended periods of time. The sensor shows a very small concentration drift even with small sample volumes. The measurement variation was less than 2 mM at low chloride ion concentration (10 mM) and 5 mM at high concentration (150 mM), spanning the range for healthy individuals and CF patients. Finally, in on-body tests we show that the sweat chloride concentration in healthy individuals is dependent on exercise intensity, indicating that the sensor has a potential for a fitness monitoring applications. (C) 2017 Elsevier B.V. All rights reserved.
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