Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 243, Issue -, Pages 761-764Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.12.057
Keywords
Colorimetric sensor; Host-guest; Polymer bead; Smartphone; Pyrophosphate; Indicator Displacement Assay
Funding
- The School of Life and Environmental Sciences and The Centre for Chemistry and Biotechnology, Deakin University
- [STEC-22-2016-LONG]
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Inorganic pyrophosphate is a molecule of significant biological importance, which has roles in metabolism and disease diagnosis. In this communication we demonstrate a novel platform for the colorimetric naked eye detection of pyrophosphate using a threshold test in both aqueous solutions and biological fluids. Our system uses peptide synthesis resin as a solid support for a bis-Zn(II)dipicolylamino mediated indicator displacement assay. Our threshold tests are able to detect pyrophosphate in concentrations as low as 1 mM. (C) 2016 Elsevier B.V. All rights reserved.
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