Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 249, Issue -, Pages 691-699Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.04.080
Keywords
Carbon nanotube; DNA; Chemiresistor; Biosensor; Hybridization
Funding
- European Social Fund [100234682]
- European Union (ERDF)
- German Research Foundation (DFG) within the Cluster of Excellence Center for Advancing Electronics Dresden [EXC 1056]
- German Academic Exchange Service (DAAD)
- Mexican National Council for Science and Technology (CONACYT)
- China Scholarship Council (CSC)
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We developed chemiresistor-type biosensors based on carbon nanotubes for highly efficient and fast detection of avian influenza virus (AIV) subtype H5N1 DNA sequences. Semiconducting single-walled carbon nanotubes (sc-SWCNTs) or nitrogen-doped multi-walled carbon nanotubes (N-MWCNTs) were used as two alternative active sensing elements, and their sensitivity to different concentrations of DNA target were compared. In these sensors long nanotubes (>5 mu m)were placed between interdigitated metal electrodes so that individual nanotubes connect the electrodes. The nanotubes were functionalized with DNA probe sequences non-covalently attached to the sidewalls. Such functionalized-nanotube sensors could reliably detect complementary DNA target sequences of the AIV H5N1 with concentration ranging from 2 pM to 2 nM in 15 min and at room temperature. Our nanotube-based biosensors are small, flexible, disposable and easy-to-fabricate that makes them promising for point-of-care applications and clinical diagnostics. (C) 2017 Elsevier B.V. All rights reserved.
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