Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 241, Issue -, Pages 1050-1056Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.10.039
Keywords
Intramolecular charge transfer; Formaldehyde; TD-DFT; Zebrafish bioimaging; Fluorescent probe
Funding
- National Nature Science Foundation of China [21272212, 21472172]
- Zhejiang Nature Science Foundation [LY17B060009]
- Project of Science Technology Department of Zhejiang Province [2014C33141]
- Project of Department of Science Technology Jinhua City [2013-3-003]
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We report a novel turn-on two-photon fluorescent probe (TPNF) for detecting formaldehyde based on aza-Cope rearrangement and intramolecular charge transfer (ICT). The probe, containing a 1,8-naphthalimide dye with a homoallylamino group, has was shown with high selectivity, sensitivity and low cytotoxicity and it was capable of detecting formaldehyde in live cells. Moreover, a time-dependent density functional theory (TD-DFT) calculation was performed to demonstrate the turn on mechanism of the probe via ICT effect. Finally, a zebrafish larvae imaging experiment reveals that TPNF displayed a significant signal change when treated with FA in vivo. These results indicated that TPNF is a promising tool in more biomedical researches. (C) 2016 Elsevier B.V. All rights reserved.
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