Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 47, Pages 15063-15067Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708271
Keywords
C-H activation; flow chemistry; heterocycles; manganese; reaction mechanisms
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Funding
- European Research Council under the European Community's Seventh Framework Program (FP7 2007-2013)/ERC Grant [307535]
- CSC
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Chemoselective hydroarylations were accomplished by a novel synergistic Bronsted acid/manganese(I)-catalyzed C-H activation manifold. Thus, alkynes bearing O-leaving groups could, for the first time, be employed for C-H alkenylations without concurrent beta-O elimination, thereby setting the stage for versatile late-stage diversifications. Also described is the first manganese-catalyzed C-H activation in continuous flow, thus enabling efficient hydroarylations within only 20 minutes.
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