Journal
SENSORS
Volume 17, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/s17112452
Keywords
functionalization; microfluidics; surface acoustic waves (SAWs)
Funding
- Nanotechnology-based therapy and diagnostics of brain diseases project (NanoBrain-Progetto BANDIERA Nanomax) of the Italian National Research Council
- GLIOMICS - Proteomica/genomica/metabolomica per l'individuazione di biomarcatori e lo sviluppo di una piattaforma di rivelazione ultrasensibile in fluidi corporei periferici: applicazione al glioblastoma multiforme project of Regione Toscana
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Surface chemical and biochemical functionalization is a fundamental process that is widely applied in many fields to add new functions, features, or capabilities to a material's surface. Here, we demonstrate that surface acoustic waves (SAWs) can enhance the chemical functionalization of gold films. This is shown by using an integrated biochip composed by a microfluidic channel coupled to a surface plasmon resonance (SPR) readout system and by monitoring the adhesion of biotin-thiol on the gold SPR areas in different conditions. In the case of SAW-induced streaming, the functionalization efficiency is improved times with respect to the case without SAWs. The technology here proposed can be easily applied to a wide variety of biological systems (e.g., proteins, nucleic acids) and devices (e.g., sensors, devices for cell cultures).
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