Journal
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 3, Issue 2, Pages 79-89Publisher
SPRINGER
DOI: 10.1016/j.fjps.2017.04.002
Keywords
Azodye; Schiff bases; Antimicrobial activity
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In the present investigation, a series of novel 4 (5-(10-(3-(N,N-dimethylamino)propyl)-10H-phenothiazine-3-yl)-1,3,4-thiadiazo-2-yl) Azo dye/Schiff base derivatives (5a-e & 6a-j) were synthesised by performing diazotization followed by coupling reaction between 4-(5-(10-(3-(N,N-dimethylamino)propyl)-10H-phenothiazine-3yl)-1,3,4-thiadiazole-2-amine, sodium nitrite, Con HCl and the different coupling reagent/condensation reaction of 4-(5-(10-(3-(N,N-dimethylamino)propyl)-10H-phenothiazine-3yl)-1,3,4-thiadiazole-2-amine and different aromatic aldehyde. The structures of these compounds were confirmed by FT-IR, H-1 NMR, Mass spectroscopy and elemental analysis. In vitro antibacterial and antifungal activities of these compounds were screened against the different strains such as P. Aeruginosa (ATCC-2853), E. Coli (ATCC-25922), S. Epidermidis (ATCC-155), A. Fumigatus (ATCC-46645), S. Aureus (ATCC-9144), A. Niger (ATCC-9029) by disc diffusion and minimum inhibitory concentrations (MIC) method. The results revealed that compound N-(4-chlorobenzylidene)-5-(10-(3-(N,N-dimethylamino)propyl)-10H-phenothiazine-3y1)-1,3,4-thiadiazole-2-amine (6d) showed promising anti-microbial activity against various pathogenic microorganisms as compared to the antibiotics Ciprofloxacin and Fluconazole. (C) 2017 Future University. Production and hosting by Elsevier B.V.
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