Journal
BIOINFORMATION
Volume 13, Issue 6, Pages 192-195Publisher
BIOMEDICAL INFORMATICS
DOI: 10.6026/97320630013192
Keywords
antibiotic resistant; penicillin binding protein; antimicrobial peptide; peptide designing
Categories
Funding
- UGC
- CSIR
Ask authors/readers for more resources
Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits better at the ligand-binding site of mutant PBP5 compared to wild type PBP5. It is expected that the designed peptide will halt the growth of drug resistant pathogen harboring mutant variety of PBP5. We have recommended experimental validation of the above concept.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available