Journal
SENSORS
Volume 17, Issue 7, Pages -Publisher
MDPI AG
DOI: 10.3390/s17071601
Keywords
sibutramine hydrochloride; Surface Enhanced Raman Scattering; beta-cyclodextrin; polyvinyl alcohol
Funding
- National Natural Science Foundation of China (NSFC) [21177044, 21377169]
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Sibutramine hydrochloride (SH) is a banned weight-loss drug, but its illegal addition to health products is still rampant. This suggests a very urgent need for a fast and precise detection method for SH. Surface Enhanced Raman Scattering (SERS) is a promising candidate for this purpose, but the weak affinity between SH and bare metal limits its direct SERS detection. In the present work, -cyclodextrin was capped in situ onto the surface of Ag nanoparticles to function as a scaffold to capture SH. The obtained Ag nanoparticles were encapsulated into polyvinyl alcohol (PVA) to fabricate a SERS active hydrogel with excellent reproducibility. A facile SERS strategy based on such substrate was proposed for trace SH quantification with a linear range of 7.0-150.0 mu gmL(-1), and a detection limit low to 3.0 mu gmL(-1). It was applied to analyze seven types of commercial slimming capsules with satisfactory results, showing good prospect for real applications.
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