Journal
SENSORS
Volume 17, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/s17102436
Keywords
fluorescent boron sensor; BNCT; boron pharmaceutical; boron(III) complex
Funding
- Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering grant program for biomedical engineering research
- Japan Agency for Medical Research and Development, AMED
- Grants-in-Aid for Scientific Research [16H02612, 15K21291] Funding Source: KAKEN
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Novel boron-containing drugs have recently been suggested as a new class of pharmaceuticals. However, the majority of current boron-detection techniques require expensive facilities and/or tedious pretreatment methods. Thus, to develop a novel and convenient detection method for boron-based pharmaceuticals, imine-type boron-chelating-ligands were previously synthesized for use in a fluorescent sensor for boronic acid containing compounds. However, the fluorescence quantum yield of the imine-type sensor was particularly low, and the sensor was easily decomposed in aqueous media. Thus, in this paper, we report the development of a novel, convenient, and stable fluorescent boron-sensor based on O- and N-chelation (i.e., 2-(pyridine-2yl)phenol), and a corresponding method for the quantitative and qualitative detection of boronic acid-containing compounds using this commercially available sensor is presented.
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