Journal
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Volume 22, Issue 14, Pages 10569-10579Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-015-4249-5
Keywords
Cadmium; Utero and lactation exposure; Low doses; Development; Reproduction
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Funding
- Natural Science Foundation of China [81402656]
- Chongqing Municipal Science and Technology Commission Fundamental Research funded project [2014cstc-jbky-01711]
- Third Military Medical University [2012XJQ07]
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Cadmium (Cd) is an important toxic chemical due to its increasing levels in the environment and its resulting accumulation in humans and animals. The present study was performed to evaluate the long-term effects of low doses of Cd administered in offspring by oral route to rats during pregnancy and lactation. There were no adverse effects on the physical and sexual development in the pups, except to delay the development of offspring. The relative weights of livers and kidneys in the adult female offspring were significantly decreased after exposure to 10 ppm Cd. These results indicated that there were adverse effects on growth and development from exposure to 5 or 10 ppm Cd in utero and during lactation. The results also showed differential gender sensitivity effects on the organ weights.
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