Journal
ACS NANO
Volume 11, Issue 1, Pages 1054-1063Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b07927
Keywords
multifunctional reagents; photoacoustic imaging; phototherapy; organic nanoparticles; tumor
Categories
Funding
- National Natural Science Foundation of China [61525402, 21275076]
- 973 program [2014CB660808]
- Key University Science Research Project of Jiangsu Province [15KJA430006]
- QingLan Project
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Herein, a donor-acceptor-donor (D-A-D) structured small molecule (DPP-TPA) is designed and synthesized for photoacoustic imaging (PAI) guided photo dynamic/photothermal synergistic therapy. In the diketopyrrolopyrrole (DPP) molecule, a thiophene group is contained to increase the intersystem crossing (ISC)-ability through the heavy atom effect. Simultaneously, triphenylamine (TPA) is introduced for bathochromic shift absorption as well as charge transport capacity enhancement. After formation of nanoparticles (NPs, similar to 76 nm) by reprecipitation, the absorption of DPP-TPA NPs further displays obvious bathochromic-shift with the maximum absorption peak at 660 nm. What's more, the NPs architecture enhances the D-A-D structure, which greatly increases the charge transport capacity and impels the charge to generate heat by light. DPP-TPA NPs present high photothermal conversion efficiency (eta = 34.5%) and excellent singlet oxygen (102) generation (Phi(Delta) = 33.6%) under 660 nm laser irradiation. PM, with high spatial resolution and deep biotissue penetration, indicates DPP-TPA NPs can rapidly target the tumor sites within 2 h by the enhanced permeability and retention (EPR) effect. Importantly, DPP-TPA NPs could effectively hinder the tumor growth by photodynamic/photothermal synergistic therapy in vivo even at a low dosage (0.2 mg/kg) upon laser irradiation (660 nm 1.0 W/cm(2)). This study illuminates the photothermal conversion mechanism of small organic NPs and demonstrates the promising application of DPP-TPA NPs in PM guided phototherapy.
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