Journal
GUT MICROBES
Volume 8, Issue 4, Pages 323-334Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2017.1279380
Keywords
adaptation; amino acids; biofilm; chicken; chemotaxis; colonization; methyl accepting chemoreceptors; motility; organic acids; Tlps; virulence
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Funding
- Ohio Agricultural Research and Development Center (OARDC)
- Ohio State University
- Agriculture and Food Research Initiative (AFRI), U. S. Department of Agriculture [2012-68003-19679]
- NIFA [2012-68003-19679, 578602] Funding Source: Federal RePORTER
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Chemotaxis, a process that mediates directional motility toward or away from chemical stimuli (chemoeffectors/ligands that can be attractants or repellents) in the environment, plays an important role in the adaptation of Campylobacter jejuni to disparate niches. The chemotaxis system consists of core signal transduction proteins and methyl-accepting-domain-containing Transducer like proteins (Tlps). Ligands binding to Tlps relay a signal to chemotaxis proteins in the cytoplasm which initiate a signal transduction cascade, culminating into a directional flagellar movement. Tlps facilitate substrate-specific chemotaxis in C. jejuni, which plays an important role in the pathogen's adaptation, pathobiology and colonization of the chicken gastrointestinal tract. However, the role of Tlps in C. jejuni's host tissue specific colonization, physiology and virulence remains not completely understood. Based on recent studies, it can be predicted that Tlps might be important targets for developing strategies to control C. jejuni via vaccines and antimicrobials.
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