Journal
BIOMATERIALS
Volume 113, Issue -, Pages 80-92Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.09.028
Keywords
SLIPS; Perfluorocarbon liquids; Polytetrafluoroethylene; Implant; Infection; In vivo
Funding
- Defense Advanced Research Projects Agency [N66001-11-1-4180, HR0011-13-C-0025]
- NIH [T32 HL 008843-21A1, T35 HL 110843]
- American College of Surgeons Resident Research Scholarship
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Virtually all biomaterials are susceptible to biofilm formation and, as a consequence, device-associated infection. The concept of an immobilized liquid surface, termed slippery liquid-infused porous surfaces (SLIPS), represents a new framework for creating a stable, dynamic, omniphobic surface that displays ultralow adhesion and limits bacterial biofilm formation. A widely used biomaterial in clinical care, expanded polytetrafluoroethylene (ePTFE), infused with various perfluorocarbon liquids generated SLIPS surfaces that exhibited a 99% reduction in S. aureus adhesion with preservation of macrophage viability, phagocytosis, and bactericidal function. Notably, SLIPS modification of ePTFE prevents device infection after S. aureus challenge in vivo, while eliciting a significantly attenuated innate immune response. SLIPS-modified implants also decrease macrophage inflammatory cytokine expression in vitro, which likely contributed to the presence of a thinner fibrous capsule in the absence of bacterial challenge. SLIPS is an easily implementable technology that provides a promising approach to substantially reduce the risk of device infection and associated patient morbidity, as well as health care costs. (C) 2016 Elsevier Ltd. All rights reserved.
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