Journal
TISSUE BARRIERS
Volume 5, Issue 4, Pages -Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/21688370.2017.1345353
Keywords
apoptosis; epithelia; extrusion; phagocytosis; tissue mechanics
Categories
Funding
- International Postgraduate Research Scholarship
- UQ Centennial Scholarship
- Australian Research Council [FT160100366, FT130100361]
- NHMRC Australia [1107914, 1044041]
- National Health and Medical Research Council of Australia [1107914] Funding Source: NHMRC
- Australian Research Council [FT160100366, FT130100361] Funding Source: Australian Research Council
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Apoptosis is a ubiquitous mode of programmed cell death that is found in healthy organs and can be stimulated by many toxic stresses. When it occurs in epithelia, apoptosis presents major challenges to tissue integrity. Apoptotic corpses can promote inflammatory and autoimmune responses if they are retained, and the cellular fragmentation that accompanies apoptosis can potentially compromise the epithelial barrier. Here we discuss 2 homeostatic mechanisms that allow epithelia to circumvent these potential risks: clearance of apoptotic corpses by professional and non-professional phagocytes and physical expulsion of apoptotic cells by apical extrusion. Extrusion and phagocytosis may represent complementary responses that preserve epithelial integrity despite the inevitable challenge of apoptosis.
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