Journal
TRANSCRIPTION-AUSTIN
Volume 8, Issue 5, Pages 328-342Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21541264.2017.1329000
Keywords
coactivator; eukaryotic transcription; functional genomics; genetics; human; Mediator; preinitiation complex; RNA polymerase II; structural biology; yeast Saccharomyces cerevisiae
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Funding
- Agence Nationale de la Recherche [ANR-14-CE10-0012-01]
- Fondation ARC [SL220130607079]
- Fondation pour la Recherche Medicale [FDT20150531985]
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Mediator is a multisubunit complex conserved in eukaryotes that plays an essential coregulator role in RNA polymerase (Pol) II transcription. Despite intensive studies of the Mediator complex, the molecular mechanisms of its function in vivo remain to be fully defined. In this review, we will discuss the different aspects of Mediator function starting with its interactions with specific transcription factors, its recruitment to chromatin and how, as a coregulator, it contributes to the assembly of transcription machinery components within the preinitiation complex (PIC) in vivo and beyond the PIC formation.
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