Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 39, Issue 5, Pages 517-528Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-017-0639-8
Keywords
Cytokine; Inflammation; Innate immunity; Sepsis; Endothelium
Categories
Funding
- French National Research Agency (ANR) (Project CMOS) [ANR-15-CE15-0019]
Ask authors/readers for more resources
Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical syndrome related to the host response to infection. The severity of infections is due to an activation cascade that will lead to an autoamplifying cytokine production: the cytokine storm. Cytokines are a broad category of relatively small proteins (<40 kDa) that are produced and released with the aim of cell signaling. Our understanding of the processes that trigger this tremendous amount of cytokine production has made dramatic progress over the last decades, but unfortunately, these findings could not translate yet into effective treatments; so far, all clinical trials targeting cytokine production or effects failed. This review aims to summarize the pathophysiology of the cytokine storm; to describe the type, effects, and kinetics of cytokine production; and to discuss the therapeutic challenges of targeting cytokines. New promising therapeutic strategies focusing on the endothelium, as a source and a target of cytokines, are described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available