Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 22, Issue 4, Pages 267-274Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2017.06.003
Keywords
Mechanical ventilation; Ventilator-associated lung injury; Volume-targeted ventilation; Lung-protective ventilation
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Funding
- Draeger Medical Inc.
- Windtree Therapeutics
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Although only a small proportion of full term and late preterm infants require invasive respiratory support, they are not immune from ventilator-associated lung injury. The process of lung damage from mechanical ventilation is multifactorial and cannot be linked to any single variable. Atelectrauma and volutrauma have been identified as the most important and potentially preventable elements of lung injury. Respiratory support strategies for full term and late preterm infants have not been as thoroughly studied as those for preterm infants; consequently, a strong evidence base on which to make recommendations is lacking. The choice of modalities of support and ventilation strategies should be guided by the specific underlying pathophysiologic considerations and the ventilatory approach must be individualized for each patient based on the predominant pathophysiology at the time. (C) 2017 Elsevier Ltd. All rights reserved.
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