Journal
SEMINARS IN DIAGNOSTIC PATHOLOGY
Volume 34, Issue 2, Pages 153-159Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semdp.2016.12.011
Keywords
Cirrhosis; Diagnosis; Treatment; Locoregional therapy; Resection; Liver transplantation; Barcelona Clinic Liver Cancer system; Screening
Categories
Funding
- Novate Medical (Dublin, Ireland)
- BTG (London, United Kingdom)
- Cook, Inc. (Bloomington, IN)
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Hepatocellular carcinoma is a leading cancer worldwide. Its incidence is increasing, and is closely related to advanced liver disease. Cirrhosis represents the greatest risk factor for this malignancy, and is the main indication for screening and surveillance. The diagnosis of hepatocellular carcinoma can frequently, and uniquely, be made on characteristic multiphase contrast based cross-sectional imaging rather than strict need for tissue sampling. Despite advances in medical, locoregional and surgical therapies, hepatocellular carcinoma remains one of the most common causes of cancer-related death globally. In this review, current approaches to management of hepatocellular carcinoma are discussed, which incorporate both tumor and patient factors. The salient considerations in surgical (resection, liver transplantation), locoregional (ablation and embolic therapies) and medical therapies are highlighted. (C) 2017 Elsevier Inc. All rights reserved.
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