4.2 Article

Panniculitis: A summary

Journal

SEMINARS IN DIAGNOSTIC PATHOLOGY
Volume 34, Issue 3, Pages 261-272

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semdp.2016.12.004

Keywords

Pannniculitis; Vasculitis; Erythema nodosum; Lipodermatosclerosis; Post-irradiation panniculitis; Morphea profunda; Behcet disease; Polyarteritis nodosa; Necrobiosis lipoidica; Erythema induratum, pancreatogenic panniculitis; Alpha-1-antitrypsin deficiency; Lupus erythematosus; Dermatomyositis; Sweet syndrome; Infectious panniculitis; Eosinophilic panniculitis; Factitial panniculitis; Cold panniculitis; Sclerema neonatorum; Subcutaneous fat necrosis of the newborn

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The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. Septocentric, non-vasculitis disorders include erythema nodosum, panniculitis that follows the use of biological therapeutic agents, lipodermatosclerosis, post-irradiation panniculitis, morphea profunda, and necrobiosis lipodica profunda. Polyarteritis nodosa and Behcet's disease are the conditions that are based in the subcutaneous septa with vasculitis. Predominantly-lobular panniculitides with no vasculitis include pancreatogenic panniculitis, the panniculitis of alpha-1-antitrypsin deficiency, panniculitis associated with lupus erythematosus and dermatomyositis, subcutaneous Sweet syndrome, eosinophilic panniculitis, factitial panniculitis, cold panniculitis, panniculitis following injections of corticosteroids, lipomembranous (ischemic) panniculitis; sclerema neonatorum and subcutaneous fat necrosis of the newborn, and Rosai-Dorfman disease of the subcutis. Erythema induratum and infectious panniculitis are vasculitic and lobulocentric conditions. This article reviews the histological features of these diseases. (C) 2017 Elsevier Inc. All rights reserved.

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