Journal
SEMINARS IN DIAGNOSTIC PATHOLOGY
Volume 34, Issue 2, Pages 160-166Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semdp.2016.12.012
Keywords
Periductal cholangiocarcinoma; Infiltrating cholangiocarcinoma; Mass forming cholangiocarcinoma; Cholangiolocellular carcinoma; Victoria blue stain
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Cholangiocarcinoma, also referred to as cholangiocellular carcinoma (particularly in Japan), develops along the biliary tract. The tumor may be intra- or extrahepatic and have different features with specific treatments based on the site of origin. Guidelines for diagnosis and management of cholangiorcarcinoma, such as those proposed by EASL (European Association for the Study of the Liver)(1) and the Mayo Clinic(2) classify the tumor into intrahepatic, perihilar, and distal cholangiocarcinoma. There are three main macroscopic patterns of growth of cholangiocarcinoma: mass-forming, periductal-infiltrating and intraductal. A combination of mass-forming and periductal infiltrating tumors have been shown to have a poor prognosis.(3) Intrahepatic cholangiocarcinoma (ICC) comprises two microscopic subtypes: bile duct and cholangiolar.(4) The bile duct subtype has tall columnar cells that form large glands, whereas cholangiolar tumors are composed of cuboidal and low columnar cells. Patients with cholangiolar tumors, referred to as cholangiolocellular carcinoma, reportedly have a better 5-year survival rate than those with the bile duct type.(4) (C) 2017 Elsevier Inc. All rights reserved.
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