Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 69, Issue -, Pages 70-82Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.05.027
Keywords
p120ctn; delta-catenin; p0071; ARVCF; Neuron
Categories
Funding
- Munroe-Meyer Institute
- Alzheimer's association
- Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health [5P20GM103471-10]
- Nebraska EPSCoR [EPS-1004094]
- National Institutes of Health [1R03MH110726-01]
- University of Nebraska Medical Center
- Nebraska Research Initiative
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The cadherin-catenin complex in central neurons is associated with a variety of cytosolic partners, collectively called catenins. The p120ctn members are a family of catenins that are distinct from the more ubiquitously expressed alpha- and beta-catenins. It is becoming increasingly clear that the functional roles of the p120ctn family of catenins in central neurons extend well beyond their functional roles in non-neuronal cells in partnering with cadherin to regulate adhesion. In this review, we will provide an overview of the p120ctn family in neurons and their varied functional roles in central neurons. Finally, we will examine the emerging roles of this family of proteins in neurodevelopmental disorders. (C) 2017 Elsevier Ltd. All rights reserved.
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