Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 68, Issue -, Pages 72-84Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.05.006
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- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [R01AR065083]
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The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins), and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to pathogenic disease onset and progression. Recent advances in the study of the regulation of NPC composition and function suggest that the precise control of this structure is necessary to prevent diseases from arising or progressing. Here we discuss the role of nucleoporins in a diverse set of diseases, many of which directly or indirectly increase in occurrence and severity as we age, and often shorten the human lifespan. NPC biology has been shown to play a direct role in these diseases and therefore in the process of healthy aging. (C) 2017 Elsevier Ltd. All rights reserved.
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