Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 67, Issue -, Pages 113-122Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.05.011
Keywords
MET; EMT; Cell mechanics; Phenotypic plasticity; Cell and tissue polarity; Epithelial-to-mesenchymal transition; Re-epithelialization; Reverse-EMT; Epithelialization; Polarization
Categories
Funding
- NIH [R01 HD044750]
- NSF [CBET-1547790]
- Cardiovascular Bioengineering Training Program (NIH NHLBI) [T32 HL076124]
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The mesenchymal-to-epithelial transition (MET) is an intrinsically mechanical process describing a multi-step progression where autonomous mesenchymal cells gradually become tightly linked, polarized epithelial cells. METs are fundamental to a wide range of biological processes, including the evolution of multicellular organisms, generation of primary and secondary epithelia during development and organogenesis, and the progression of diseases including cancer. In these cases, there is an interplay between the establishment of cell polarity and the mechanics of neighboring cells and microenvironment. In this review, we highlight a spectrum of METs found in normal development as well as in pathological lesions, and provide insight into the critical role mechanics play at each step. We define MET as an independent process, distinct from a reverse-EMT, and propose questions to further explore the cellular and physical mechanisms of MET. (C) 2016 Elsevier Ltd. All rights reserved.
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