Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 65, Issue -, Pages 11-19Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.06.016
Keywords
Host-pathogen; Bacteria; microRNA; IncRNA; Regulatory network
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Funding
- European Research Council advanced grant [BacCellEpi-670823]
- ERA-NET Infect-ERA ProAntiLis
- Investissements d'Avenir BACNET [ANR-10-BINF-0201]
- IBEID [ANR-10-LABX-62-01]
- Human Frontier Science Program [RGP0011/2013]
- Fondation le Roch Les Mousquetaires
- Fondation pour la Recherche Medicale [FRM-AJE20131128944]
- Inserm ATIP-Avenir
- Mairie de Paris (Programme Emergences Recherche medicale)
- Investissements d'Avenir MemoLife [ANR-10-LABX-54]
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Gene expression regulation is a critical question in host-pathogen interactions, and RNAs act as key players in this process. In this review, we focus on the mammalian RNA response to bacterial infection, with a special interest on microRNAs and long non-coding RNAs. We discuss the role of cellular miRNAs in immunity, the implication of circulating miRNAs as well as the influence of the microbiome on the miRNA response. We also review how pathogens counteract the host miRNA expression. Interestingly, bacterial non-coding RNAs regulate host gene expression and conversely eukaryotic miRNAs may regulate bacterial gene expression. Overall, the characterization of RNA regulatory networks represents an emerging theme in the field of host pathogen interactions. (C) 2016 The Authors. Published by Elsevier Ltd.
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