Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 61, Issue -, Pages 41-50Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.08.007
Keywords
Interleukin 33; ST2; Tissue damage; Fibrosis; Tumorigenesis
Categories
Funding
- Versus Arthritis [21346] Funding Source: Medline
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IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular alarmin. Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis. (C) 2016 Elsevier Ltd. All rights reserved.
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