Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 69, Issue -, Pages 91-101Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.06.001
Keywords
Fat cadherins; Fat-like cadherins; Neural development; Tissue polarity; Planar polarity
Categories
Funding
- National Eye Institute (NIH) [R01 EY024884]
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Atypical Fat cadherins represent a small but versatile group of signaling molecules that influence proliferation and tissue polarity. With huge extracellular domains and intracellular domains harboring many independent protein interaction sites, Fat cadherins are poised to translate local cell adhesion events into a variety of cell behaviors. The need for such global coordination is particularly prominent in the nervous system, where millions of morphologically diverse neurons are organized into functional networks. As we learn more about their biological functions and molecular properties, increasing evidence suggests that Fat cadherins mediate contact-induced changes that ultimately impose a structure to developing neuronal circuits. (C) 2017 Elsevier Ltd. All rights reserved.
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