Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 68, Issue -, Pages 34-41Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.06.026
Keywords
Nuclear transport receptors; Nucleoporins; Nucleocytoplasmic transport; Multivalency; Intrinsically disordered protein
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Funding
- ERC grant SMPF v2.0
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The nuclear pore complex (NPC) forms a permeability barrier between the nucleus and the cytoplasm. Molecules that are able to cross this permeability barrier encounter different disordered phenylalanine glycine rich nucleoporins (FG-Nups) that act as a molecular filter and regulate the selective NPC crossing of biomolecules. In this review, we provide a current overview regarding the interaction mechanism between FG-Nups and the carrier molecules that recognize and enable the transport of cargoes through the NPC aiming to understand the general molecular mechanisms that facilitate the nucleocytoplasmic transport. (C) 2017 The Authors. Published by Elsevier Ltd.
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