Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 71, Issue -, Pages 146-152Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.05.014
Keywords
Stretch; Epithelial tubes; Smooth muscle; Mechanotransduction; Contractility; Integrin signaling; Calcium; RhoA
Categories
Funding
- National Institutes of Health NIGMS [GM110268]
- Ministry of Education [MOE2015-T2-1-045]
Ask authors/readers for more resources
Many tissues in our body have a tubular shape and are constantly exposed to various stresses. Luminal pressure imposes tension on the epithelial and myoepithelial or smooth muscle cells surrounding the lumen of the tubes. Contractile forces generated by actomyosin assemblies within these cells oppose the luminal pressure and must be calibrated to maintain tube diameter homeostasis and tissue integrity. In this review, we discuss mechanotransduction pathways that can lead from sensation of cell stretch to activation of actomyosin contractility, providing rapid mechanochemical feedback for proper tubular tissue function. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available