Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 67, Issue -, Pages 170-176Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.06.003
Keywords
Quantitative models; Morphodynamics; Mechanobiology; Turing patterns
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Funding
- NIH [GM083997, HL110335, HL118532, HL120142]
- National Science Foundation Grant [CMMI-1435853]
- David and Lucile Packard Foundation
- Sloan Foundation
- Camille & Henry Dreyfus Foundation
- Burroughs Wellcome Fund
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1435853] Funding Source: National Science Foundation
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The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture. In this review, we focus on three different theoretical approaches - geometric modeling, reaction-diffusion modeling, and continuum mechanical modeling - and discuss how, taken together, these models have identified the geometric principles necessary to build an efficient bronchial network, as well as the patterning mechanisms that specify airway geometry in the developing embryo. We emphasize models that are integrated with biological experiments and suggest how recent progress in computational modeling has advanced our understanding of airway branching morphogenesis. (C) 2016 Elsevier Ltd. All rights reserved.
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