Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 65, Issue -, Pages 20-28Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.05.017
Keywords
Argonaute; miRNA; Target Search; Lateral diffusion; Single molecule; FRET; Free-energy landscape; Theoretical model; RNA silencing; Search stability paradox; MicroRNA target prediction
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Funding
- European Research Council [309509]
- TU Delft start up
- Netherlands Organization for Scientific Research (NWO/OCW)
- European Research Council (ERC) [309509] Funding Source: European Research Council (ERC)
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MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss recent single-molecule and high-resolution structural data in the light of theoretical work appropriated from the study of transcription-factor search. We suggest that experimentally observed internal states of the Ago-miRNA search complex may have the explicit biological function of speeding up search while maintaining specificity. (C) 2016 The Authors. Published by Elsevier Ltd.
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