Journal
SEMINARS IN CANCER BIOLOGY
Volume 47, Issue -, Pages 185-195Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2017.08.001
Keywords
Tumor metastasis; Microenvironment; Tumor suppressor; Inflammation/Immune; Heterogeneity
Categories
Funding
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
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Treatment of cancer metastasis has been largely ineffective. It is paramount to understand the mechanisms underlying the metastatic process, of which the tumor microenvironment is an indispensable participant. What are the critical cellular and molecular players at the primary tumor site where metastatic cascade initiates? How is tumor-associated inflammation regulated? How do altered vasculatures contribute to metastasis? What is the dynamic nature or heterogeneity of primary tumors and what are the challenges to catch a moving target? This review summarizes recent progress, mechanistic understanding, and options for metastasis-targeted therapy.
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