Journal
SEMINARS IN CANCER BIOLOGY
Volume 47, Issue -, Pages 170-176Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2017.08.006
Keywords
Metastasis; Inflammation; Cancer; Immunology
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Funding
- CRUK Career Development Award Fellowship [C49791/A17367]
- ERC Starting Grant [716379]
- European Research Council (ERC) [716379] Funding Source: European Research Council (ERC)
- Cancer Research UK [17367] Funding Source: researchfish
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Metastatic disease is the major challenge of cancer that accounts for over 90% of total cancer lethality. Mounting clinical and preclinical data now indicate that inflammation, a potent immune and repair response, is indispensable for metastasis. In this review we describe our current understanding of how major inflammatory cells contribute to metastatic cascade with a focus on the primary tumour. We also discuss exciting new directions for future research and novel therapeutic approaches to tackle metastatic disease through targeting inflammation.
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