Journal
SEMINARS IN CANCER BIOLOGY
Volume 47, Issue -, Pages 1-17Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2017.05.004
Keywords
Mitochondria; Cancer; Mitochondrial DNA; Mipigenetics; Numtogenesis; Intercellular; Retrograde; Mitochondria-to-nucleus; Anterograde; Nucleus-to-mitochondria; Nuclear mitochondria; miRNA; Cancer prevention; Therapy; Extracellular ATP; Epigenetic; Exosome
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Funding
- NIH grant [R01 1R01CA204430]
- Veterans Administration grant [5I01BX001716]
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Mitochondria are complex intracellular organelles that have long been identified as the powerhouses of eukaryotic cells because of the central role they play in oxidative metabolism. A resurgence of interest in the study of mitochondria during the past decade has revealed that mitochondria also play key roles in cell signaling, proliferation, cell metabolism and cell death, and that genetic and/or metabolic alterations in mitochondria contribute to a number of diseases, including cancer. Mitochondria have been identified as signaling organelles, capable of mediating bidirectional intracellular information transfer: anterograde (from nucleus to mitochondria) and retrograde (from mitochondria to nucleus). More recently, evidence is now building that the role of mitochondria extends to intercellular communication as well, and that the mitochondrial genome (mtDNA) and even whole mitochondria are indeed mobile and can mediate information transfer between cells. We define this promiscuous information transfer function of mitochondria and mtDNA as momiome to include all mobile functions of mitochondria and the mitochondrial genome. Herein, we review the momiome and explore its role in cancer development, progression, and treatment.
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