Journal
NATURE REVIEWS CANCER
Volume 17, Issue 1, Pages 65-74Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc.2016.113
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Funding
- Canadian Cancer Society Research Institute (CCSRI) [701603]
- CCSRI [703458]
- National Institutes of Health (NIH) [R01 CA195670]
- NIH [R01 CA196619, R01 CA141154, R01 CA136891, P30 CA046592, R21 CA178571]
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Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.
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